Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease.
نویسندگان
چکیده
Platelet factor 4 (PF4) and heparin (H) form PF4/H complexes, the target of the immune reaction in heparin-induced thrombocytopenia (HIT). HIT seems to be a secondary immune response as anti-PF4/H-IgG antibodies occur as early as day 4 of heparin treatment. This study investigated whether prevalent infections such as periodontitis may induce the PF4/H immune response as: (1) natural anti-PF4/H Abs are present in the normal population; (2) PF4 bound to bacteria exposes the same antigen(s) as PF4/H complexes; and (3) sepsis induces PF4/H Abs in mice. We found PF4 bound to periodontal pathogens (Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis) enabling subsequent binding of human anti-PF4/H Abs. The association of natural PF4/H Abs and periodontitis was assessed in a case-control study, enrolling individuals with natural anti-PF4/H Abs (n = 40 matched pairs), and in the cross-sectional population-based Study of Health in Pomerania (SHIP; n = 3500). Both studies showed a robust association between periodontitis and presence of anti-PF4/H Abs independent of inflammation markers (case-control study: lowest vs highest tertile, odds ratio, 7.12 [95% confidence interval, 1.73-46.13; P = .005]; SHIP study, p(trend) ≤ 0.001). Thus, preimmunization to PF4/bacteria complexes by prevalent infections, for example, periodontitis, likely explains the presence of natural anti-PF4/heparin Abs and the early occurrence of anti-PF4/H-IgG in HIT.
منابع مشابه
THROMBOSIS AND HEMOSTASIS Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease
1Institut für Immunologie und Transfusionsmedizin, 2Poliklinik für Zahnerhaltung, Parodontologie und Endodontologie, 3Zentrum für InnovationskompetenzHumorale Immunreaktionen bei kardiovaskulären Erkrankungen, 4Abteilung Genetik der Mikroorganismen, Interfakultäres Institut für Genetik und Funktionelle Genomforschung, and 5Institut für Community Medicine, Ernst-Moritz-Arndt-Universität, Greifsw...
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عنوان ژورنال:
- Blood
دوره 118 5 شماره
صفحات -
تاریخ انتشار 2011